In this Marvel Villainous expansion, players take the role of Venom, a hungry and murderous alien symbiote. To win as Venom, players must bond Spider-Man with the symbiote by overwhelming him with a number of symbiote tokens greater than his Strength. Allies like the symbiotes Agony, Lasher, Scream, Phage, and Riot help Venom achieve his goal while heroes like Black Cat, Scarlet Spider, and Silver Sable get in his way.